Structure of PDB 6b16 Chain A

Receptor sequence
>6b16A (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
EEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
QPKKELIINEILVMRENKNPNIVNYLDSYLDELWVVMEYLAGGSLTDVVT
ETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTD
FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM
IEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVE
KRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK
3D structure
PDB6b16 Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors.
ChainA
Resolution2.285 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N389 K391 D393 N394 D407 P416 T427
Catalytic site (residue number reindexed from 1) N132 K134 D136 N137 D150 P159 T170
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C7Y A A297 E345 Y346 L347 D393 L396 T406 A47 E88 Y89 L90 D136 L139 T149 MOAD: Ki=32nM
PDBbind-CN: -logKd/Ki=7.49,Ki=32nM
BindingDB: Ki=32nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6b16, PDBe:6b16, PDBj:6b16
PDBsum6b16
PubMed27346791
UniProtQ13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (Gene Name=PAK1)

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