Structure of PDB 6b0t Chain A

Receptor sequence
>6b0tA (length=487) Species: 9606 (Homo sapiens) [Search protein sequence]
AEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAG
SAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSE
AHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLS
ARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARP
EPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFAL
EQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCA
FRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVT
SKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDA
NRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFC
DYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
3D structure
PDB6b0t Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C7V A L16 L48 Q50 W101 L103 E215 F216 R217 L10 L42 Q44 W95 L97 E209 F210 R211
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0005515 protein binding
GO:0030674 protein-macromolecule adaptor activity
GO:0045296 cadherin binding
GO:0051015 actin filament binding
Biological Process
GO:0007015 actin filament organization
GO:0007043 cell-cell junction assembly
GO:0007163 establishment or maintenance of cell polarity
GO:0010592 positive regulation of lamellipodium assembly
GO:0016477 cell migration
GO:0030035 microspike assembly
GO:0030036 actin cytoskeleton organization
GO:0030046 parallel actin filament bundle assembly
GO:0032534 regulation of microvillus assembly
GO:0032956 regulation of actin cytoskeleton organization
GO:0035089 establishment of apical/basal cell polarity
GO:0048870 cell motility
GO:0051017 actin filament bundle assembly
GO:0051491 positive regulation of filopodium assembly
GO:0071803 positive regulation of podosome assembly
GO:0090091 positive regulation of extracellular matrix disassembly
Cellular Component
GO:0001725 stress fiber
GO:0001726 ruffle
GO:0002102 podosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005902 microvillus
GO:0005911 cell-cell junction
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030426 growth cone
GO:0031253 cell projection membrane
GO:0042995 cell projection
GO:0044393 microspike
GO:0070062 extracellular exosome
GO:0070161 anchoring junction

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6b0t, PDBe:6b0t, PDBj:6b0t
PDBsum6b0t
PubMed29573988
UniProtQ16658|FSCN1_HUMAN Fascin (Gene Name=FSCN1)

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