Structure of PDB 6b0o Chain A

Receptor sequence

>6b0oA (length=119) Species: 9606 (Homo sapiens) [Search protein sequence]

HMRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSD
QLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSC
QKKFARSDELVRHHNMHQR

3D structure

PDB

6b0o Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.

Chain

Resolution

1.552 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R321 K332 Y334 H339 K346 F364 R366 Q369 R372 H373 R376 R390 S393 R394 H397 H401 T404 R424 E427 R430	R3 K14 Y16 H21 K28 F46 R48 Q51 R54 H55 R58 R72 S75 R76 H79 H83 T86 R106 E109 R112	PDBbind-CN: Kd=45nM
BS02	dna	A	Y353 S367 K371 D396 K399 S425 R430	Y35 S49 K53 D78 K81 S107 R112	PDBbind-CN: Kd=45nM
BS03	ZN	A	C355 C360 H373 H377	C37 C42 H55 H59
BS04	ZN	A	C385 C388 H401 H405	C67 C70 H83 H87
BS05	ZN	A	C413 C418 H431 H435	C95 C100 H113 H117
BS06	ZN	A	C325 C330 H343 H347	C7 C12 H25 H29

External links

PDB	RCSB:6b0o, PDBe:6b0o, PDBj:6b0o
PDBsum	6b0o
PubMed	29294058
UniProt	P19544\|WT1_HUMAN Wilms tumor protein (Gene Name=WT1)

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