Structure of PDB 6b0f Chain A

Receptor sequence
>6b0fA (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTADQMVSALLDAEPPILYSSEASMMGLLTNLADRELVHMINWAKRVPG
FVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDVEGMV
EIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGHIHRVLDKITDTLIH
LMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYKSKNVVPLYDLL
LEML
3D structure
PDB6b0f Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.
ChainA
Resolution2.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C6V A M343 L346 T347 E353 L387 F404 M421 I424 F425 H524 L525 Y526 K531 N532 V533 M27 L30 T31 E37 L71 F88 M99 I102 F103 H186 L187 Y188 K191 N192 V193 BindingDB: IC50=6.0nM
External links
PDB RCSB:6b0f, PDBe:6b0f, PDBj:6b0f
PDBsum6b0f
PubMed29562737
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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