Structure of PDB 6azp Chain A

Receptor sequence
>6azpA (length=577) Species: 9606 (Homo sapiens) [Search protein sequence]
CPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPG
VKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFT
PEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSC
PACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVN
QRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMH
TLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLV
LGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRY
QPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVD
EIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQ
LGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIG
TQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNN
IFMSNSYPRDFVNCSTLPALNLASWRE
3D structure
PDB6azp A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN).
ChainA
Resolution2.291 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.11.2.2: myeloperoxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D262 T334 F336 D338 S340 D96 T168 F170 D172 S174
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0020037 heme binding
Biological Process
GO:0006979 response to oxidative stress

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Molecular Function
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Biological Process
External links
PDB RCSB:6azp, PDBe:6azp, PDBj:6azp
PDBsum6azp
PubMed29306874
UniProtP05164|PERM_HUMAN Myeloperoxidase (Gene Name=MPO)

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