Structure of PDB 6ayw Chain A

Receptor sequence
>6aywA (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
TRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY
YSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLAD
FGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYIL
LVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
AKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKL
3D structure
PDB6ayw The structure of human CamKII with bound inhibitor
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D136 K138 E140 N141 D157 T177
Catalytic site (residue number reindexed from 1) D129 K131 E133 N134 D150 T170
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2V A L20 V28 A41 F90 V93 N141 L143 D157 L13 V21 A34 F83 V86 N134 L136 D150 BindingDB: IC50=37nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6ayw, PDBe:6ayw, PDBj:6ayw
PDBsum6ayw
PubMed
UniProtQ13557|KCC2D_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit delta (Gene Name=CAMK2D)

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