Structure of PDB 6ayb Chain A

Receptor sequence

>6aybA (length=449) Species: 5763 (Naegleria fowleri) [Search protein sequence]

KLPPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFL
NHPKILDTFFKATDNELSLRDVYRFMRPVFGTGVVYDADSTERMMEQVKF
VSSGLTTARFRVFVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTASR
CLLGDEVRQYLSEKNLGKLYHDIDDGISPLSFFYPSLPAPKRDKARKAVG
EIFQELLDKRREEHKKHPERLLDESKMDVVDHLLTQKYKDGQELTDVHRI
GILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLD
YDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVV
SPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGEN
FALLQVKSIISILLRYFDMEYIGKIPDPSYTSLVVGPSPPTRMRYKLRK

3D structure

PDB

6ayb CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).

Chain

Resolution

1.87 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	A	Y107 Y120 A293 T297 L358 I361 R363 P422 F423 H428 C430 I431 G432	Y73 Y86 A259 T263 L324 I327 R329 P388 F389 H394 C396 I397 G398
BS02	CA	A	L84 N85 V384 S385	L50 N51 V350 S351
BS03	KKK	A	Y107 F109 F114 Y120 P213 F217 A289 F292 A293 T297 L358 M360	Y73 F75 F80 Y86 P179 F183 A255 F258 A259 T263 L324 M326

Gene Ontology

	Molecular Function
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:6ayb, PDBe:6ayb, PDBj:6ayb
PDBsum	6ayb
PubMed	29284029
UniProt	A0A2H4A2U9

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