Structure of PDB 6ay4 Chain A

Receptor sequence
>6ay4A (length=450) Species: 5763 (Naegleria fowleri) [Search protein sequence]
KLPPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFL
NHPKILDTFFKATDNELSLRDVYRFMRPVFGTGVVYDADSTERMMEQVKF
VSSGLTTARFRVFVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTASR
CLLGDEVRQYLSEKNLGKLYHDIDDGISPLSFFYPSLPAPKRDKARKAVG
EIFQELLDKRREEHKKHPERLLDESKMDVVDHLLTQKYKDGQELTDVHRI
GILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLD
YDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVV
SPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGEN
FALLQVKSIISILLRYFDMEYIGKIPDPSYTSLVVGPSPPTRMRYKLRKQ
3D structure
PDB6ay4 CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A A293 G294 T297 P357 L358 R363 P422 F423 G424 H428 C430 I431 A259 G260 T263 P323 L324 R329 P388 F389 G390 H394 C396 I397
BS02 TPF A Y107 M110 F114 Y120 A289 F292 A293 L358 Y73 M76 F80 Y86 A255 F258 A259 L324
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6ay4, PDBe:6ay4, PDBj:6ay4
PDBsum6ay4
PubMed29284029
UniProtA0A2H4A2U9

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