Structure of PDB 6ax4 Chain A

Receptor sequence
>6ax4A (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYG
LGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSL
MKKITLLKYFRNYMSEHLLKAGANITPRDELARLPYLRTWFRTRSAIILH
LSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCK
ELASRLRYARTMVDKLLSSRS
3D structure
PDB6ax4 Histidine N( tau )-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K413 W414 V415 D416 Y417 L478 Y481 Y485 L490 L491 R516 F535 H538 K540 K41 W42 V43 D44 Y45 L106 Y109 Y113 L118 L119 R142 F161 H164 K166
External links
PDB RCSB:6ax4, PDBe:6ax4, PDBj:6ax4
PDBsum6ax4
PubMed30174151
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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