Structure of PDB 6ax1 Chain A

Receptor sequence
>6ax1A (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMG
LDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVF
LLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVL
NLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAV
SRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGA
YHVLHKELPEVTNSVFHEINMWVSQRTATA
3D structure
PDB6ax1 Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.23: acylglycerol lipase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C0S A G50 A51 S122 M123 N152 G33 A34 S105 M106 N135 PDBbind-CN: -logKd/Ki=9.42,IC50=0.38nM
BindingDB: IC50=0.380000nM
BS02 GOL A G50 A51 H121 H269 G33 A34 H104 H252
BS03 GOL A K165 I211 K148 I194
Gene Ontology
Molecular Function
GO:0004622 lysophospholipase activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0047372 monoacylglycerol lipase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006639 acylglycerol metabolic process
GO:0006954 inflammatory response
GO:0009966 regulation of signal transduction
GO:0016042 lipid catabolic process
GO:0019369 arachidonate metabolic process
GO:0019433 triglyceride catabolic process
GO:0046464 acylglycerol catabolic process
GO:0050727 regulation of inflammatory response
GO:0051930 regulation of sensory perception of pain
GO:0052651 monoacylglycerol catabolic process
GO:2000124 regulation of endocannabinoid signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ax1, PDBe:6ax1, PDBj:6ax1
PDBsum6ax1
PubMed29148769
UniProtQ99685|MGLL_HUMAN Monoglyceride lipase (Gene Name=MGLL)

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