Structure of PDB 6ate Chain A

Receptor sequence
>6ateA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLPEAFEAQVM
KKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV
DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLPIKW
TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG
YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ
PGENL
3D structure
PDB6ate Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.
ChainA
Resolution2.402 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D389 R391 A393 N394 D407
Catalytic site (residue number reindexed from 1) D122 R124 A126 N127 D140
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6H3 A L276 C280 V284 A296 Y343 M344 S345 G347 L396 A406 D407 L17 C21 V25 A37 Y76 M77 S78 G80 L129 A139 D140
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ate, PDBe:6ate, PDBj:6ate
PDBsum6ate
PubMed30982749
UniProtP12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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