Structure of PDB 6aqr Chain A

Receptor sequence
>6aqrA (length=442) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHE
INSGATFMCLQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCED
YIGNIDLINDAILAKYWDDVCTKTMVPSMERRDGLSGLINMGSTAFMSSI
LQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGALNST
NRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVLDLPNA
QCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKKKLYEC
LDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLL
NGSNRKLDDFIEFPTYLNMKNYCSTKVPDIIYELIGIVSHKGTVNEGHYI
AFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN
3D structure
PDB6aqr Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C46 C49 C68 H73 C45 C48 C67 H72
BS02 ZN A C60 C63 H77 H83 C59 C62 H76 H82
BS03 ZN A C4 H6 C96 C99 C3 H5 C95 C98
BS04 ZN A H170 C174 C182 C185 H169 C173 C181 C184
BS05 ZN A H250 C271 C273 H276 H240 C252 C254 H257
BS06 ZN A C289 C292 C336 C339 C270 C273 C317 C320
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0060090 molecular adaptor activity
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006508 proteolysis
GO:0008380 RNA splicing
GO:0016579 protein deubiquitination
Cellular Component
GO:0000124 SAGA complex
GO:0005634 nucleus
GO:0046695 SLIK (SAGA-like) complex
GO:0071819 DUBm complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6aqr, PDBe:6aqr, PDBj:6aqr
PDBsum6aqr
PubMed30150323
UniProtP50102|UBP8_YEAST Ubiquitin carboxyl-terminal hydrolase 8 (Gene Name=UBP8)

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