Structure of PDB 6aqf Chain A

Receptor sequence
>6aqfA (length=390) Species: 562,9606 [Search protein sequence]
DGAPPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVS
LAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLA
IAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCG
QPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVY
LRIFLAARRQLADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALD
AQKMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQK
YLERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAP
LWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH
3D structure
PDB6aqf Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor.
ChainA
Resolution2.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZMA A L85 F168 M177 L249 H250 N253 I274 L88 F171 M180 L333 H334 N337 I358 PDBbind-CN: -logKd/Ki=8.67,Kd=2.14nM
BS02 CLR A P248 I251 I252 S263 P332 I335 I336 S347
BS03 CLR A F255 F258 F339 F342
BS04 CLR A A72 G76 I80 A75 G79 I83
Gene Ontology
Molecular Function
GO:0001609 G protein-coupled adenosine receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0001973 G protein-coupled adenosine receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6aqf, PDBe:6aqf, PDBj:6aqf
PDBsum6aqf
PubMed29290469
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P29274|AA2AR_HUMAN Adenosine receptor A2a (Gene Name=ADORA2A)

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