Structure of PDB 6alb Chain A

Receptor sequence
>6albA (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
SRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIV
KNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCS
KLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYLCTIPRDAAYYSYQN
RYHFCEKCFDPSQPQTTEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDI
IWPSGFVCDNCL
3D structure
PDB6alb Design and Synthesis of A Biaryl Series As Inhibitors for the Bromodomains of CBP/P300
ChainA
Resolution2.053 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1199 C1200 H1291 C1294 C120 C121 H191 C194
BS02 ZN A C1283 C1286 C1308 C1311 C183 C186 C208 C211
BS03 ZN A C1213 C1219 C134 C137
BS04 BKJ A L1109 P1110 L1120 N1168 V1174 F1177 L30 P31 L41 N89 V95 F98 BindingDB: IC50=1.2nM,EC50=32nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6alb, PDBe:6alb, PDBj:6alb
PDBsum6alb
PubMed
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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