Structure of PDB 6akx Chain A

Receptor sequence
>6akxA (length=339) Species: 1501,9606 [Search protein sequence]
KINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINYKRLKSMTDIYLLN
LAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIIL
LTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPNIIFTRSQK
EGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTL
LRMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQ
FEEVEEEKKRHRDVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCS
SSNRLDQAMQVTETLGMTHCCINPIIYAFVGEEFRNYLL
3D structure
PDB6akx Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1006 C1009 C1039 C1042 C208 C211 C241 C244
BS02 A4R A Y37 W86 Y89 Y108 F109 F112 I198 Y251 L255 E283 Y16 W65 Y68 Y87 F88 F91 I177 Y281 L285 E313
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0016493 C-C chemokine receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0043448 alkane catabolic process
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6akx, PDBe:6akx, PDBj:6akx
PDBsum6akx
PubMed30234300
UniProtP00268|RUBR_CLOPA Rubredoxin;
P51681

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