Structure of PDB 6ak7 Chain A

Receptor sequence
>6ak7A (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
ISLAKVGCASQIGKRKENEDRFDFAQLTDEVLYFAVYDGHGGPAAADFCH
THMEKCIMDLLPKEANLETLLTLAFLEIDKAFSSHARLSADATLLTSGTT
ATVALLRDGIELVVASVGDSRAILCRKGKPMKLTIDHTPERADEKERIKK
CGGFVAWNQPHVNGRLAMTRSIGDLDLKTSGVIAEPETKRIKLHHADDSF
LVLTTDGINFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTEDNSTAV
VVPFGAW
3D structure
PDB6ak7 Structure of PPM1K-N94K mutant at 2.61 Angstroms resolution
ChainA
Resolution2.605 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
3.1.3.52: [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]- phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D127 D298 D337 D38 D206 D245
BS02 MG A D127 G128 D38 G39
BS03 MG A D112 E143 D23 E54
BS04 MG A D208 D298 D119 D206
Gene Ontology
Molecular Function
GO:0004722 protein serine/threonine phosphatase activity
GO:0043169 cation binding
Biological Process
GO:0006470 protein dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6ak7, PDBe:6ak7, PDBj:6ak7
PDBsum6ak7
PubMed
UniProtQ8N3J5|PPM1K_HUMAN Protein phosphatase Mn(2+)-dependent 1K (Gene Name=PPM1K)

[Back to BioLiP]