Structure of PDB 6ajg Chain A

Receptor sequence
>6ajgA (length=900) Species: 10665,246196 [Search protein sequence]
FQSNAMFAWWGRTVYQFRYIVIGVMVALCLGGGVYGISLGNHVTQSGFYD
EGSQSVAASLIGDEVYGRDRTSHVVAILTPPDDKKVTDKAWQKKVTEELD
QVVKDHEDQIVGWVGWLKAPDTTDPTVSAMKTQDLRHTFISIPLQGDDDD
EILKNYQVVEPELQQVNGGDIRLAGLNPLASELTGTIGEDQKRAEVAAIP
LVAVVLFFVFGTVIAAALPAIIGGLAIAGALGIMRLVAEFTPVHFFAQPV
VTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTVMTSGRTVVFSAV
IIVASSVPLLLFPQGFLKSITYAIIASVMLAAILSITVLAAALAILGPRV
DALGVTTLLFWGRLVNVVMKRPIAFAAPILVVMVLLIIPLGQLSLGGISE
KYLPPDNAVRQSQEQFDKLFPGFRTEPLTLVMKREDGEPITDAQIADMRA
KALTVSGFTDPDNDPEKMWKERPANDSGSKDPSVRVIQNGLENRNDAAKK
IDELRALQPPHGIEVFVGGTPALEQDSIHSLFDKLPLMALILIVTTTVLM
FLAFGSVVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLMA
PMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLI
TGAALILAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAVMK
LLGDDCWWAPRWMKRVQEKEFNIFEMLRIDEGLRLKIYKDTEGYYTIGIG
HLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILR
NAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAA
VNLAKSRWYNQTPNRAKRVITTFRTGTWDAYEFHLGGIKAFHHHHHHHHH
3D structure
PDB6ajg Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
ChainA
Resolution2.604 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3RX A I249 I253 F260 I297 V638 L642 D645 Y646 F649 I254 I258 F265 I302 V609 L613 D616 Y617 F620
BS02 MHA A T891 P892 N893 R894 I917 K918 T862 P863 N864 R865 I888 K889
BS03 MHA A G862 F863 T864 N865 S866 N881 G833 F834 T835 N836 S837 N852
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ajg, PDBe:6ajg, PDBj:6ajg
PDBsum6ajg
PubMed30682372
UniProtA0QP27|MMPL3_MYCS2 Trehalose monomycolate exporter MmpL3 (Gene Name=mmpL3);
D9IEF7

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