Structure of PDB 6ajc Chain A

Receptor sequence
>6ajcA (length=413) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
SQKIKVAGTVVELDGDEMTRVIWKMIKEELIFPFLDVPIEYYDLGMENRD
KTDDQVTVDAAHAIKKHGVGVKCATITPDEARVREFNLKQMWKSPNGTIR
NILGGTVFREPIMCKNVPRLVTTWKHPIVIGRHAFGDQYRATDLVVNGPG
TFEIHFVPESGGAAQVQKVFDFKSGGVLMGMYNTDESIKDFAKSCFEYAL
SKKWPLYLSTKNTILKRYDGRFKDIFAEMYKASYEADYKKAGIWYEHRLI
DDMVAYAMKSEGGYVWACKNYDGDVQSDSVAQGFGSLGLMTSVLMSPDGR
TVEAEAAHGTVTRHYRQHQKGEETSTNPVASIFAWTRGLMHRGKLDQNEK
LVQFSMLLEKVVVSTIEAGFMTKDLAICIKGMNHVTRSDYLNTQEFIHKL
ADEMRKAYERSKI
3D structure
PDB6ajc Biochemical characterization of a novel Trypanosoma brucei glycosomal isocitrate dehydrogenase with dual coenzyme specificity (NADP+/NAD+)
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A T75 I76 T77 N96 L287 A307 H308 G309 T310 V311 R313 H314 N327 T75 I76 T77 N96 L287 A307 H308 G309 T310 V311 R313 H314 N327
BS02 CA A D274 D278 D274 D278
BS03 NAP A D252 K259 D252 K259
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006739 NADP metabolic process
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ajc, PDBe:6ajc, PDBj:6ajc
PDBsum6ajc
PubMed
UniProtQ4E4L7

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