Structure of PDB 6aim Chain A

Receptor sequence
>6aimA (length=308) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
EEQYFKTNPKPAYIDELIKDAKEFIDLQYSLKRNKIVLITSGGTTVPLEN
NTVRFIDNFSAGTRGASSAEQFLANGYSVIFLHREFSLTPYNRSFSHSIN
TLFLDYIDSEGKIKPEFAENVLKNKKLYDKYMEKEEKLLLLPFTTVNQYL
WSLKSIAKLLNNSGCLFYLAAAVSDFFVPYSRLPQHKIQEGTTRTTPDGK
LIVNLDPVPKFLRRLVESWATQAMIVSFKLETDESMLLYKCTQALDRYNH
QLVIGNLLQTRNKQVIFVSPENRKGDWVRLDEKHASIEEMIIPEVIARHD
KWVAHSKT
3D structure
PDB6aim Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.
ChainA
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.5: phosphopantothenate--cysteine ligase (CTP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9Z3 A S99 A100 G101 T102 R103 A209 A210 F280 K281 L282 N308 R313 S60 A61 G62 T63 R64 A170 A171 F228 K229 L230 N256 R261
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004632 phosphopantothenate--cysteine ligase activity
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:1990143 CoA-synthesizing protein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6aim, PDBe:6aim, PDBj:6aim
PDBsum6aim
PubMed30653991
UniProtP40506|PPCS_YEAST Phosphopantothenate--cysteine ligase CAB2 (Gene Name=CAB2)

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