Structure of PDB 6ai7 Chain A

Receptor sequence
>6ai7A (length=329) Species: 31958 (Amycolatopsis orientalis) [Search protein sequence]
ADLERAARDVLPGEIFDFLAGGSGTEASLVANRTALERVFVIPRMLRDLT
DVTTEIDIFGRRAALPMAVAPVAYQRLFHPEGELAVARAARDAGVPYTIC
TLSSVSLEEIAAVGGRPWFQLFWLRDEKRSLDLVRRAEDAGCEAIVFTVD
VPWMGRRLRDMRNGFALPEWVTAANFDFAPATWESVEAVRAHTDLPVVLK
GILAVEDARRAVDAGAGGIVVSNHGGRQLDGAVPGIEMLGEIVAAVSGGC
EVLVDGGIRSGGDVLKATALGASAVLVGRPVMWALAAAGQDGVRQLLELL
AEEVRDAMGLAGCESVGAARRLNTKLGVV
3D structure
PDB6ai7 The crystal structure of Mandelate oxidase mutant-Y128F with the C4a-OH-FMN adduct
ChainA
Resolution2.07 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F128 D156 H252
Catalytic site (residue number reindexed from 1) F122 D150 H224
Enzyme Commision number 1.1.3.46: 4-hydroxymandelate oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9Q6 A L25 P77 F128 T154 K228 H252 R255 D283 G285 R287 G306 R307 L19 P71 F122 T148 K200 H224 R227 D255 G257 R259 G278 R279
Gene Ontology
Molecular Function
GO:0004459 L-lactate dehydrogenase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0033072 vancomycin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6ai7, PDBe:6ai7, PDBj:6ai7
PDBsum6ai7
PubMed
UniProtO52792|HMO_AMYOR 4-hydroxymandelate oxidase (Gene Name=hmo)

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