Structure of PDB 6ahs Chain A

Receptor sequence
>6ahsA (length=224) Species: 10090 (Mus musculus) [Search protein sequence]
IIDGYKCKEGSHPWQVALLKGNQLHCGGVLVDKYWVLTAAHCKMGQYQVQ
LGSDKIGDQSAQKIKATKSFRHPGYSTKTHVNDIMLVRLDEPVKMSSKVE
AVQLPEHCEPPGTSCTVSGWGTTTSPDVTFPSDLMCSDVKLISSRECKKV
YKDLLGKTMLCAGIPDSKTNTCNGDSGGPLVCNDTLQGLVSWGTYPCGQP
NDPGVYTQVCKYKRWVMETMKTHR
3D structure
PDB6ahs Discovery and structure-activity relationship of imidazolinylindole derivatives as kallikrein 7 inhibitors.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 N192 G193 D194 S195
Catalytic site (residue number reindexed from 1) H41 D83 N173 G174 D175 S176
Enzyme Commision number 3.4.21.117: stratum corneum chymotryptic enzyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9YO A H57 H99 T190 C191 N192 S214 W215 G216 T217 C220 H41 H80 T171 C172 N173 S191 W192 G193 T194 C197 MOAD: ic50=1.5uM
BindingDB: IC50=1500nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0002803 positive regulation of antibacterial peptide production
GO:0006508 proteolysis
Cellular Component
GO:0001533 cornified envelope
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0097209 epidermal lamellar body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ahs, PDBe:6ahs, PDBj:6ahs
PDBsum6ahs
PubMed30522951
UniProtQ91VE3|KLK7_MOUSE Kallikrein-7 (Gene Name=Klk7)

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