Structure of PDB 6ago Chain A

Receptor sequence
>6agoA (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
GKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLS
GYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQ
RHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMI
EQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGV
YRIGLYALKDMPAGTELTYDYNFHSFNVECKCGFEKCRGIIG
3D structure
PDB6ago Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase by Releasing an Autoinhibitory Loop.
ChainA
Resolution3.103 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A E2149 K2150 G2151 W2152 S2191 D2192 Y2194 R2214 F2215 I2216 N2217 H2218 Y2255 K2269 C2270 E115 K116 G117 W118 S157 D158 Y160 R180 F181 I182 N183 H184 Y221 K231 C232
BS02 ZN A C2220 C2270 C186 C232
BS03 ZN A C2091 C2093 C2104 C2108 C57 C59 C70 C74
BS04 ZN A C2104 C2117 C2122 C70 C83 C88
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:6ago, PDBe:6ago, PDBj:6ago
PDBsum6ago
PubMed30827841
UniProtQ9NR48|ASH1L_HUMAN Histone-lysine N-methyltransferase ASH1L (Gene Name=ASH1L)

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