Structure of PDB 6ael Chain A

Receptor sequence
>6aelA (length=725) Species: 10090 (Mus musculus) [Search protein sequence]
KSWVEETCESIDTPECPAEFESPPTLLFSLDGFRAEYLHTWGGLLPVISK
LKNCGTYTKNMRPMYPTKAFPNHYSIVTGLYPESHGIIDNKMYDPKMNAS
FSLKSKEKFNPLWYKGQPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIY
KVYNGSVPFEERILAVLEWLQLPSHERPHFYTLYLEEPDSSGHSHGPVSS
EVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYL
NKYLGDVNNVKVVYGPAARLRPTDVPETYYSFNYEALAKNLSCREPNQHF
RPYLKPFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGS
DNLFSNMQALFIGYGPAFKHGAEVDSFENIEVYNLMCDLLGLIPAPNNGS
HGSLNHLLKKPIYNPSHPKEEGFLSQCPIKSTSNDLGCTCDPWIVPIKDF
EDDIYHMTVPYGRPRILLKQHRVCLLQQQQFLTGYSLDLLMPLWASYTFL
SNDQFSRDDFSNCLYQDLRIPLSPVHKCSYYKSNSKLSYGFLTPPRLNRV
SNHIYSEALLTSNIVPMYQSFQVIWHYLHDTLLQRYAHERNGINVVSGPV
FDFDYDGRYDSLEILKQNSRVIRSQEILIPTHFFIVLTSCKQLSETPLEC
SALESSAYILPHRPDNIESCTHGKRESSWVEELLTLHRARVTDVELITGL
SFYQDRQESVSELLRLKTHLPIFSQ
3D structure
PDB6ael Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
3.6.1.9: nucleotide diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4BW A A238 F239 N259 K277 Y322 Y353 D358 H362 S514 G515 H517 A69 F70 N90 K108 Y153 Y184 D189 H193 S345 G346 H348
BS02 ZN A D358 H362 H517 D189 H193 H348
BS03 ZN A D200 D405 H406 D31 D236 H237
BS04 CA A D780 D782 D784 R786 Y787 D788 D602 D604 D606 R608 Y609 D610
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6ael, PDBe:6ael, PDBj:6ael
PDBsum6ael
PubMed30356045
UniProtP06802|ENPP1_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Gene Name=Enpp1)

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