Structure of PDB 6aej Chain A

Receptor sequence
>6aejA (length=421) Species: 9606 (Homo sapiens) [Search protein sequence]
RGSHMTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHG
CLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKEAEIA
AACETFLKLNDYLQIETIQALEELAADIKSRAAYNVTLLNFMDPQKMPYL
KEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGRDPDIWHVGFKISW
DIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECST
GTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEW
LRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPV
EQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEK
DDASMPLPFDLTDIVSELRGQ
3D structure
PDB6aej Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.-
1.14.11.53: mRNA N(6)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7YC A Y108 N205 H231 D233 E234 Y295 V309 R316 S318 T320 R322 Y82 N140 H166 D168 E169 Y217 V231 R238 S240 T242 R244
BS02 ZN A H231 D233 H307 H166 D168 H229
Gene Ontology
Molecular Function
GO:0035515 oxidative RNA demethylase activity
GO:0035516 broad specificity oxidative DNA demethylase activity
Biological Process
GO:0006307 DNA alkylation repair
GO:0040014 regulation of multicellular organism growth
GO:0042245 RNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6aej, PDBe:6aej, PDBj:6aej
PDBsum6aej
PubMed30996080
UniProtQ9C0B1|FTO_HUMAN Alpha-ketoglutarate-dependent dioxygenase FTO (Gene Name=FTO)

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