Structure of PDB 6aei Chain A

Receptor sequence
>6aeiA (length=642) Species: 10090 (Mus musculus) [Search protein sequence]
LSAEEKAFLSAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAI
ENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSQFSEFTPDITP
IMLAAHTNNYEIIKLLVQKRVTIPRPHQIDSLRHSRSRLNIYKALASPSL
IALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQ
ARSSRELEIILNHRDDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFP
GWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICH
TASYLTFLFMLLLASQHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGF
TEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLI
AEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLV
LLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFW
SVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNS
YQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNILIQNQHYQEVIRNL
VKRYVAAMIRNSKTNEGLTEENFKELKQDISSFRYEVLDLLG
3D structure
PDB6aei Cryo-EM structure of TRPC5 at 2.8- angstrom resolution reveals unique and conserved structural elements essential for channel function.
ChainA
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A Y316 W322 F364 L493 L496 F497 A499 N500 Y246 W252 F294 L416 L419 F420 A422 N423
BS02 Y01 A F522 L526 L529 F445 L449 L452
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6aei, PDBe:6aei, PDBj:6aei
PDBsum6aei
PubMed31355338
UniProtQ9QX29|TRPC5_MOUSE Short transient receptor potential channel 5 (Gene Name=Trpc5)

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