Structure of PDB 6ad4 Chain A

Receptor sequence
>6ad4A (length=1300) Species: 10116 (Rattus norvegicus) [Search protein sequence]
ADELVFFVNGKKVVEKNADPETTLLVYLRRKLGLCGTKLGCGEGGCGACT
VMISKYDRLQNKIVHFSVNACLAPICSLHHVAVTTVEGIGNTQKLHPVQE
RIARSHGSQCGFCTPGIVMSMYTLLRNQPEPTVEEIENAFQGNLCRCTGY
RPILQGFRTFAKDGPSLFNPEDFKPLDPTQEPIFPPELLRLKDTPQKKLR
FEGERVTWIQASTMEELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPLI
VCPAWIPELNSVVHGPEGISFGASCPLSLVESVLAEEIAKLPEQKTEVFR
GVMEQLRWFAGKQVKSVASIGGNIITASPISDLNPVFMASGAKLTLVSRG
TRRTVRMDHTFFPGYRKTLLRPEEILLSIEIPYSKEGEFFSAFKQASRRE
ADIAKVTSGMRVLFKPGTIEVQELSLCFGGMADRTISALKTTPKQLSKSW
NEELLQSVCAGLAEELQLAPDAPGGMVEFRRTLTLSFFFKFYLTVLQKLG
RADLEDMCGKLDPTFASATLLFQKDPPANVQLFQEVPKDQSEEDMVGRPL
PHLAANMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKITSIDTSEAKK
VPGFVCFLTAEDVPNSNATGLFNDETVFAKDEVTCVGHIIGAVVADTPEH
AQRAARGVKITYEDLPAIITIQDAINNNSFYGSEIKIEKGDLKKGFSEAD
NVVSGELYIGGQEHFYLETNCTIAVPKGEAGEMELFVSTQNTMKTQSFVA
KMLGVPDNRIVVRVKRMGGGFGGKETRSTVVSTALALAAHKTGRPVRCML
DRDEDMLITGGRHPFLAKYKVGFMKTGTVVALEVAHFSNGGNTEDLSRSI
MERALFHMDNAYKIPNIRGTGRICKTNLPSNTAFRGFGGPQGMLIAEYWM
SEVAITCGLPAEEVRRKNMYKEGDLTHFNQKLEGFTLPRCWDECIASSQY
LARKREVEKFNRENCWKKRGLCIIPTKFGISFTLPFLNQGGALVHVYTDG
SVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIHISETSTNTVPNTSPT
AASASADLNGQGVYEACQTILKRLEPFKKKKPTGPWEAWVMDAYTSAVSL
SATGFYKTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTD
IVMDVGSSLNPAIDIGQVEGAFVQGLGLFTMEELHYSPEGSLHTRGPSTY
KIPAFGSIPIEFRVSLLRDCPNKRAIYASKAVGEPPLFLASSIFFAIKDA
IRAARAQHGDNAKQLFQLDSPATPEKIRNACVDQFTTLCVENCKSWSVRI
3D structure
PDB6ad4 Rat Xanthine oxidoreductase, D428A variant, NAD bound form
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q767 E802 R880 H884 R912 G1260 E1261
Catalytic site (residue number reindexed from 1) Q740 E775 R853 H857 R885 G1233 E1234
Enzyme Commision number 1.17.1.4: xanthine dehydrogenase.
1.17.3.2: xanthine oxidase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004854 xanthine dehydrogenase activity
GO:0004855 xanthine oxidase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043546 molybdopterin cofactor binding
GO:0046872 metal ion binding
GO:0050421 nitrite reductase (NO-forming) activity
GO:0050660 flavin adenine dinucleotide binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0070674 hypoxanthine dehydrogenase activity
GO:0070675 hypoxanthine oxidase activity
GO:0071949 FAD binding
Biological Process
GO:0000255 allantoin metabolic process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006147 guanine catabolic process
GO:0006148 inosine catabolic process
GO:0006149 deoxyinosine catabolic process
GO:0006154 adenosine catabolic process
GO:0006157 deoxyadenosine catabolic process
GO:0006161 deoxyguanosine catabolic process
GO:0006196 AMP catabolic process
GO:0006204 IMP catabolic process
GO:0007595 lactation
GO:0009114 hypoxanthine catabolic process
GO:0009115 xanthine catabolic process
GO:0010044 response to aluminum ion
GO:0010629 negative regulation of gene expression
GO:0016226 iron-sulfur cluster assembly
GO:0030856 regulation of epithelial cell differentiation
GO:0032496 response to lipopolysaccharide
GO:0034465 response to carbon monoxide
GO:0042542 response to hydrogen peroxide
GO:0043605 amide catabolic process
GO:0045602 negative regulation of endothelial cell differentiation
GO:0046038 GMP catabolic process
GO:0046055 dGMP catabolic process
GO:0046059 dAMP catabolic process
GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0097184 response to azide
GO:1900745 positive regulation of p38MAPK cascade
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001213 negative regulation of vasculogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0016529 sarcoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ad4, PDBe:6ad4, PDBj:6ad4
PDBsum6ad4
PubMed
UniProtP22985|XDH_RAT Xanthine dehydrogenase/oxidase (Gene Name=Xdh)

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