Structure of PDB 6acp Chain A

Receptor sequence
>6acpA (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
PSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGGYWRKWQAQDLAT
PLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVV
ITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGK
GAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDR
ELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRF
HFQGPCGTTLPEALA
3D structure
PDB6acp complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H4K91
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P68 T69 F70 R71 N141 D143 H158
Catalytic site (residue number reindexed from 1) P33 T34 F35 R36 N104 D106 H121
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q83 Y102 R105 I142 V221 F223 G224 E225 N226 L227 V253 V254 Y255 P256 Q46 Y65 R68 I105 V184 F186 G187 E188 N189 L190 V216 V217 Y218 P219
BS02 ZN A C166 C169 C207 C212 C129 C132 C170 C175
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6acp, PDBe:6acp, PDBj:6acp
PDBsum6acp
PubMed
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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