Structure of PDB 6aaz Chain A

Receptor sequence
>6aazA (length=265) Species: 1293038 (Methanosarcina mazei JCM 9314) [Search protein sequence]
PALTKSQTDRLEVLLNPKDEISLNSGKPFRELESELLSRRKKDLQQIYAE
ERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNELSKQIF
RVDKNFCLRPMLAPNLANYLRKLDRALPDPIKIFEIGPCYRKESDGKEHL
EEFTMLNFCQMGSGCTRENLESIITDFLNHLGIDFKIVGDSCMVFGDTLD
VMHGDLELSSAVVGPIPLDREWGIDKPWIGAGFGLERLLKVKHDFKNIKR
AARSGSYYNGISTNL
3D structure
PDB6aaz Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.
ChainA
Resolution1.842 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.26: pyrrolysine--tRNA(Pyl) ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E396 S399 E207 S210
BS02 ATP A R330 E332 H338 L339 F342 M344 E396 L397 S398 S399 G421 G423 R426 R141 E143 H149 L150 F153 M155 E207 L208 S209 S210 G232 G234 R237
BS03 9UC A A302 A306 N346 C348 F384 L407 D408 W417 A113 A117 N157 C159 F195 L218 D219 W228
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0043039 tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6aaz, PDBe:6aaz, PDBj:6aaz
PDBsum6aaz
PubMed31031143
UniProtQ8PWY1|PYLS_METMA Pyrrolysine--tRNA ligase (Gene Name=pylS)

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