Structure of PDB 6aam Chain A

Receptor sequence
>6aamA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
DPTVFHKRYLKKIRDLGGKVSLYCYDPTNTGEMVAVKALDAGPQHRSGWK
QEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSI
GLAQLLLFAQQICEGMAYLHAQHYIHRNLAARNVLLDNDRLVKIGDFGLA
KAVPPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFL
ELIGLAQGQMTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFR
PTFENLIPILKTVHEKYQG
3D structure
PDB6aam Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
ChainA
Resolution1.98 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N1023 A1025 R1027 N1028 D1041 P1064
Catalytic site (residue number reindexed from 1) N128 A130 R132 N133 D146 P155
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9T6 A L903 A928 I960 E979 Y980 V981 G984 L1030 D1041 L16 A35 I65 E84 Y85 V86 G89 L135 D146 PDBbind-CN: -logKd/Ki=8.32,IC50=4.8nM
BindingDB: IC50=4.8nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6aam, PDBe:6aam, PDBj:6aam
PDBsum6aam
PubMed30145050
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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