Structure of PDB 6aac Chain A

Receptor sequence
>6aacA (length=264) Species: 1293038 (Methanosarcina mazei JCM 9314) [Search protein sequence]
PALTKSQTDRLEVLLNPKDEISLNSGKPFRELESELLSRRKKDLQQIYAE
ERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNLSKQIFR
VDKNFCLRPMLAPNLANYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLE
EFTMLNFCQMGSGCTRENLESIITDFLNHLGIDFKIVGDSCMVFGDTLDV
MHGDLELSSAVVGPIPLDREWGIDKPWIGAGFGLERLLKVKHDFKNIKRA
ARSGSYYNGISTNL
3D structure
PDB6aac Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.
ChainA
Resolution1.479 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.26: pyrrolysine--tRNA(Pyl) ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E396 S399 E206 S209
BS02 ATP A R330 E332 H338 L339 F342 E396 L397 S398 S399 G421 G423 R426 R140 E142 H148 L149 F152 E206 L207 S208 S209 G231 G233 R236
BS03 9TR A M276 A302 A306 N346 F384 S399 L407 W417 M89 A112 A116 N156 F194 S209 L217 W227
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0043039 tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6aac, PDBe:6aac, PDBj:6aac
PDBsum6aac
PubMed31031143
UniProtQ8PWY1|PYLS_METMA Pyrrolysine--tRNA ligase (Gene Name=pylS)

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