Structure of PDB 6a7j Chain A

Receptor sequence
>6a7jA (length=407) Species: 1935 (Streptomyces violaceoruber) [Search protein sequence]
LMTRIALDPFVRDLDGESAALRAAGPLAEVELPGGVHVYAVTHHKEARAL
LTDSRVVKDINVWNAWQRGEIPADWPLIGLVNPGRSMLTVDGPDHRRLRT
LVAQALTVKRVEKLRAGIEALTNASLERLAALPAGEPVDLKAEFAYPLPM
NVISELMGVDAADHPRLKELFEKFFSTQTPPEEVPQMMADLGTLFTKIVE
EKKANPGDDLTSALIAASEDGDHLTDEEILNTLQLIIAAGHETTISLIVN
VVEALAIHPEQRKKVLSGEIPWEGVIEETLRWNTPTSHVLIRFATEDIEV
GDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATRTPNRHIAFGHGPHV
CPGAALSRLEAGIALPALYERFPELDLAVPAAELRNKPIVTQNDLHDLPV
KLGCPFG
3D structure
PDB6a7j Characterization of two steroid hydroxylases from different Streptomyces spp. and their ligand-bound and -unbound crystal structures.
ChainA
Resolution2.71 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S175 E241 T242 C350 P351 G352
Catalytic site (residue number reindexed from 1) S176 E242 T243 C351 P352 G353
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A K57 M86 H94 R98 L234 G239 T242 V288 R291 A342 F343 H348 C350 P351 K58 M87 H95 R99 L235 G240 T243 V289 R292 A343 F344 H349 C351 P352
BS02 TES A L87 F173 L234 A237 T285 L88 F174 L235 A238 T286
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6a7j, PDBe:6a7j, PDBj:6a7j
PDBsum6a7j
PubMed30552795
UniProtA0A1V0UEC8

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