Structure of PDB 6a6m Chain A

Receptor sequence
>6a6mA (length=589) Species: 280699 (Cyanidioschyzon merolae strain 10D) [Search protein sequence]
TTGVTARRIFALAWSSSATMIVIGFIASILEGATLPAFAIVFGRMFAVFT
KSKSQIEGETWKYSVGFVGIGVFEFIVAGSRTALFGIASERLARDLRVAA
FSNLVEQDVTYFDRRKAGELGGKLNNDVQVIQYSFSKLGAVLFNLAQCVV
GIIVAFIFAPALTGVLIALSPLVVLAGAAQMIEMSGNTKRSSEAYASAGS
VAAEVFSNIRTTKAFEAERYETQRYGSKLDPLYRLGRRRYISDGLFFGLS
MLVIFCVYALALWWGGQLIARGSLNLGNLLAAFFSAILGFMGVGQAAQVW
PDVTRGLGAGGELFAMIDRVPQYRRPDPGAEVVTQPLVLKQGIVFENVHF
RYPTRMNVEVLRGISLTIPNGKTVAIVGGSGAGKSTIIQLLMRFYDIEPQ
GGGLLLFDGTPAWNYDFHALRSQIGLVSQEPVLFSGTIRDNILYGKRDAT
DEEVIQALREANAYSFVMALPDGLDTEVGERGLALSGGQKQRIAIARAIL
KHPTLLCLDESTSALDAESEALVQEALDRMMASDGVTSVVIAHRLSTVAR
ADLILVMQDGVVVEQGNHSELMALGPSGFYYQLVEKQLA
3D structure
PDB6a6m Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A Y452 R455 S480 G483 K484 S485 T486 Q529 Y352 R355 S380 G383 K384 S385 T386 Q429
BS02 MG A S485 Q529 S385 Q429
BS03 DMU A G478 G479 G481 L645 Q658 D659 F679 L683 G378 G379 G381 L545 Q558 D559 F579 L583
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6a6m, PDBe:6a6m, PDBj:6a6m
PDBsum6a6m
PubMed30622258
UniProtM1VAN7

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