Structure of PDB 6a60 Chain A

Receptor sequence
>6a60A (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
ELTPDQQTLLHFIMDSYNKQRMPQEITNKFSAEENFLILTEMATNHVQVL
VEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLSDLLEERI
RNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDRE
AVEKLQEPLLDVLQKLCKIHQPENPQHFAELLGRLTELRTFNHHHAEMLM
SWRVNDHKFTPLLEEIWDV
3D structure
PDB6a60 Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
ChainA
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K303 H313 E467 K55 H65 E215
BS02 064 A Q263 M290 H294 M328 F329 R331 I335 M365 Y369 H447 W454 F461 Q20 M42 H46 M80 F81 R83 I87 M113 Y117 H195 W202 F209 BindingDB: EC50=65nM,IC50=20nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:6a60, PDBe:6a60, PDBj:6a60
PDBsum6a60
PubMed30275017
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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