Structure of PDB 6a5z Chain A

Receptor sequence
>6a5zA (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
ELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATN
HVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKSDLLE
ERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIK
DREAVEKLQEPLLDVLQKLCKIHQPENPQHFAELLGRLTELRTFNHHHAE
MLMSWRVNKFTPLLEEIWDV
3D structure
PDB6a5z Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K303 H313 I317 K321 E467 K60 H70 I74 K78 E216
BS02 9R3 A M265 M290 M328 F329 R331 I335 Y369 H447 W454 F461 M22 M47 M85 F86 R88 I92 Y120 H198 W205 F210
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:6a5z, PDBe:6a5z, PDBj:6a5z
PDBsum6a5z
PubMed30275017
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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