Structure of PDB 6a5n Chain A

Receptor sequence

>6a5nA (length=502) Species: 3702 (Arabidopsis thaliana)

GDSSRNKVKETLRLFHGVCRKILQEDEAKPEDQRRKGKGLRIDFEASTIL
KRNGKFLNSGVHILGEVPGVEVGDEFQYRMELNILGIHKPSQAGIDYMKY
GKAKVATSIVASGGYDDHLDNSDVLTYTGQGGNPEDQKLITGNLALATSI
EKQTPVRVIRGKHKSTHDKSKGGNYVYDGLYLVEKYWQQVGSHGMNVFKF
QLRRIPGQPELSWVEVKKSKSKYREGLCKLDISEGKEQSPISAVNEIDDE
KPPLFTYTVKLIYPDWCRPVPPKSCCCTTRCTEAEARVCACVEKNGGEIP
YNFDGAIVGAKPTIYECGPLCKCPSSCYLRVTQHGIKLPLEIFKTKSRGW
GVRCLKSIPIGSFICEYVGELLEDSEAERRIGNDEYLFDIGNRYDNSLAQ
GMSELMLGTQAGRSMAEGDESSGFTIDAASKGNVGRFINHSCSPNLYAQN
VLYDHEDSRIPHVMFFAQDNIPPLQELCYDYNYALDQVRDSKGNIKQKLC
FC

3D structure

• PDB: 6a5n Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
• Chain: A
• Resolution: 2.4 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.-
  2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	G302 G304 R306 Y343 R344 Q357 A358 G359 V375 S377 Y380 D382 Y392 T393 K442 K449 Y453	G37 G39 R41 Y78 R79 Q92 A93 G94 V110 S112 Y115 D117 Y127 T128 K164 K171 Y175
BS02	dna	A	F309 K316 M345 S356 Q357 K369	F44 K51 M80 S91 Q92 K104
BS03	ZN	A	C553 C569 C595 C599	C275 C291 C317 C321
BS04	ZN	A	C559 C595 C601	C281 C317 C323
BS05	ZN	A	C553 C555 C559 C567	C275 C277 C281 C289

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0042054 histone methyltransferase activity

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:6a5n, PDBe:6a5n, PDBj:6a5n
• PDBsum: 6a5n
• PubMed: 30150382
• UniProt: Q8VZ17|SUVH6_ARATH Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6 (Gene Name=SUVH6)