Structure of PDB 6a5m Chain A

Receptor sequence

>6a5mA (length=488) Species: 3702 (Arabidopsis thaliana)

DSSRNKVKETLRLFHGVCRKILQEDEAKPEDQRRKGKGLRIDFEASTILK
RNGKFLNSGVHILGEVPGVEVGDEFQYRMELNILGIHKPSQAGIDYMKYG
KAKVATSIVASGGYDDHLDNSDVLTYTGQEDQKLITGNLALATSIEKQTP
VRVIRGKHSKGGNYVYDGLYLVEKYWQQVGSHGMNVFKFQLRRIPGQPEL
SWVEVKKSKSKYREGLCKLDISEGKEQSPISAVNEIDDEKPPLFTYTVKL
IYPDWCRPVPPKSCCCTTRCTEAEARVCACVEKNGGEIPYNFDGAIVGAK
PTIYECGPLCKCPSSCYLRVTQHGIKLPLEIFKTKSRGWGVRCLKSIPIG
SFICEYVGELLEDSEAERRIGNDEYLFDIGNRYDNSLAQGMSELMESSGF
TIDAASKGNVGRFINHSCSPNLYAQNVLYDHEDSRIPHVMFFAQDNIPPL
QELCYDYNYALDQVRDSKGNIKQKLCFCGAAVCRRRLY

3D structure

• PDB: 6a5m Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
• Chain: A
• Resolution: 2.301 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.-
  2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C553 C569 C595 C599	C264 C280 C306 C310
BS02	ZN	A	C559 C595 C601 C605	C270 C306 C312 C316
BS03	ZN	A	C555 C559 C567	C266 C270 C278
BS04	ZN	A	C720 C778 C780 C785	C418 C476 C478 C483
BS05	SAM	A	R626 G627 W628 E663 Y664 R714 F715 N717 H718 Y759 K776 C778 F779 L789	R337 G338 W339 E374 Y375 R412 F413 N415 H416 Y457 K474 C476 F477 L487

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0042054 histone methyltransferase activity

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:6a5m, PDBe:6a5m, PDBj:6a5m
• PDBsum: 6a5m
• PubMed: 30150382
• UniProt: Q8VZ17|SUVH6_ARATH Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6 (Gene Name=SUVH6)