Structure of PDB 6a57 Chain A

Receptor sequence

>6a57A (length=131) Species: 3702 (Arabidopsis thaliana)

EKEEEEEEEENEEEECAAYQCNMEGCTMSFSSEKQLMLHKRNICPIKGCG
KNFFSHKYLVQHQRVHSDDRPLKCPWKGCKMTFKWAWSRTEHIRVHTGAR
PYVCAEPDCGQTFRFVSDFSRHKRKTGHSVK

3D structure

• PDB: 6a57 Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms.
• Chain: A
• Resolution: 2.7 Å

Enzymatic activity

• Enzyme Commision number: 1.14.11.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	F1277 F1278 Y1282 V1289 W1309 S1312 H1316 F1339 D1342	F53 F54 Y58 V65 W85 S88 H92 F115 D118
BS02	dna	A	W1311 Y1326 V1340 S1341 S1344 R1348	W87 Y102 V116 S117 S120 R124
BS03	ZN	A	C1250 H1263 H1280	C26 H39 H56
BS04	ZN	A	C1268 C1273 H1286 H1290	C44 C49 H62 H66
BS05	ZN	A	C1298 C1303 H1316 H1320	C74 C79 H92 H96
BS06	ZN	A	C1328 C1333 H1346 H1352	C104 C109 H122 H128

External links

• PDB: RCSB:6a57, PDBe:6a57, PDBj:6a57
• PDBsum: 6a57
• PubMed: 32257379
• UniProt: Q9STM3|REF6_ARATH Lysine-specific demethylase REF6 (Gene Name=REF6)