Structure of PDB 6a47 Chain A

Receptor sequence
>6a47A (length=224) Species: 10090 (Mus musculus) [Search protein sequence]
SEPPRAETFVFLDLEATGLPNMDPEIAEISLFAVHRSSLENPERDDSGSL
VLPRVLDKLTLCMCPERPFTAKASEITGLSSESLMHCGKAGFNGAVVRTL
QGFLSRQEGPICLVAHNGFDYDFPLLCTELQRLGAHLPQDTVCLDTLPAL
RGLDRAHSHRKSYSLASLFHRYFQAEPSAAHSAEGDVHTLLLIFLHRAPE
LLAWADEQARSWAHIEPMYVPPDG
3D structure
PDB6a47 Structural insights into the duplex DNA processing of TREX2
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E16 A17 G19 L20 P21 N22 I77 N118 Y122 R156 R167 S169 Y170 S171 L172 H188 E15 A16 G18 L19 P20 N21 I76 N117 Y121 R155 R160 S162 Y163 S164 L165 H181
BS02 MG A D14 E16 D193 D13 E15 D186
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0008296 3'-5'-DNA exonuclease activity
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6a47, PDBe:6a47, PDBj:6a47
PDBsum6a47
PubMed30357414
UniProtQ9R1A9|TREX2_MOUSE Three prime repair exonuclease 2 (Gene Name=Trex2)

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