Structure of PDB 6a46 Chain A

Receptor sequence
>6a46A (length=223) Species: 10090 (Mus musculus) [Search protein sequence]
EPPRAETFVFLDLEATGLPNMDPEIAEISLFAVHRSSLENPERDDSGSLV
LPRVLDKLTLCMCPERPFTAKASEITGLSSESLMHCGKAGFNGAVVRTLQ
GFLSRQEGPICLVAHNGFDYDFPLLCTELQRLGAHLPQDTVCLDTLPALR
GLDRAHSRKSYSLASLFHRYFQAEPSAAHSAEGDVHTLLLIFLHRAPELL
AWADEQARSWAHIEPMYVPPDGP
3D structure
PDB6a46 Structural insights into the duplex DNA processing of TREX2
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D14 E16 D193 D12 E14 D184
BS02 DCM A E16 A17 L20 K73 I77 Y122 H188 D193 E14 A15 L18 K71 I75 Y120 H179 D184
BS03 CA A S171 L172 S162 L163
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0008296 3'-5'-DNA exonuclease activity
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6a46, PDBe:6a46, PDBj:6a46
PDBsum6a46
PubMed30357414
UniProtQ9R1A9|TREX2_MOUSE Three prime repair exonuclease 2 (Gene Name=Trex2)

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