Structure of PDB 6a22 Chain A

Receptor sequence
>6a22A (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
PYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKS
MWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVL
VRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHF
SEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSI
LAKLPPAGKLASLCSQHVERLQIFQHLHPIV
3D structure
PDB6a22 Ternary crystal structure of human ROR gamma ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H322 Q329 K336 I350 L353 K354 Q487 H60 Q67 K74 I88 L91 K92 Q225
BS02 9P6 A L287 W317 C320 H323 M365 V376 F378 F388 I400 F401 L25 W55 C58 H61 M103 V114 F116 F126 I138 F139
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6a22, PDBe:6a22, PDBj:6a22
PDBsum6a22
PubMed30478402
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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