Structure of PDB 6a1d Chain A

Receptor sequence

>6a1dA (length=516) Species: 35974 (Santalum album)

ANLWDYDFLQSLGRHSSVTEEHVGLAEKLKGEVKSLITGPMEPLAKLEFI
DSVRRLGLKYQFETEMKEALANISKDGYDSWWVDNLRATALRFRLLRENG
IFVPQDVFERFQNKETGKFKNELCEDVKGLLNLYEASFLGWEGEDILDEA
RTFSTAQLKNVEGKISSPNLAKIVHHALDLPLHWRAIRYEARWFIDIYED
EEDMNPTLLKYAKLDFNIVQSFHQAEIGRLARWWVGTGLDKLPFARNGLI
QSYMYAIGMLFEPHLGEVREMEAKVGALITTIDDVYDVYGTMEELELFTD
ITERWDINRVDQLPRNIRMPLLTMFNTSNDIGYWALKERGFNGIPYTAKV
WADQLKSYTKEAKWFHEGHKPTLEEYLENALVSIGFPNLLVTSYLLTVDN
PTKEKLDYVDSLPLFVRASCILCRIINDLGTLKSIQCYMNETGASQEVAR
EHIEGLVRMWWKRLNKCLFEPSPFTEPFLSFTINVVRGSHFFYQYNAESW
TKNQGMSVLIHPITLD

3D structure

• PDB: 6a1d Crystal structure of a synthase 1 from Santalum album in complex with ligand
• Chain: A
• Resolution: 1.78 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R279 Y288 G309 D316 D320 S416 I417 G418 R457 N460 T464 Y536
• Catalytic site (residue number reindexed from 1): R246 Y255 G276 D283 D287 S383 I384 G385 R424 N427 T431 Y493

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	6R2	A	Y288 A289 I312 D316 D320 L422 R457 N460 K476 Y536	Y255 A256 I279 D283 D287 L389 R424 N427 K433 Y493
BS02	MG	A	D316 D320	D283 D287
BS03	MG	A	D316 D320	D283 D287

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0010333 terpene synthase activity
• GO:0016829 lyase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0016102 diterpenoid biosynthetic process

External links

• PDB: RCSB:6a1d, PDBe:6a1d, PDBj:6a1d
• PDBsum: 6a1d
• UniProt: A0A0A0RDR2