Structure of PDB 6a15 Chain A

Receptor sequence
>6a15A (length=439) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
TRFNLPPGKSGLGETIGYLKPYTATTLGDFMQQHVSKYGKIYRSNLFGEP
TIVSADAGLNRFILQNEGRLFECSYPRSIGGILGKWSMLVLVGDMHRDMR
SISLNFLSHARLRTILLKDVERHTLFVLDSWQQNSIFSAQDEAKKFTFNL
MAKHIMSMDPGEEETEQLKKEYVTFMKGVVSAPLNLPGTAYHKALQSRAT
ILKFIERKMEERKLDIKERKTDDDLLGWVLKHSNLSTEQILDLILSLLFA
GHETSSVAIALAIFFLQACPKAVEELREEHLEIARAKKELGESELNWDDY
KKMDFTQCVINETLRLGNVVRFLHRKALKDVRYKGYDIPSGWKVLPVISA
VHLDNSRYDQPNLFNPWRWQQQNNYMPFGGGPRLCAGSELAKLEMAVFIH
HLVLKFNWELAEDDKPFAFPFVDFPNGLLIRVSRILHHH
3D structure
PDB6a15 Structural insights into a key step of brassinosteroid biosynthesis and its inhibition.
ChainA
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.14.178: steroid 22S-hydroxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A Y112 H133 R137 M188 T315 R386 F455 R460 C462 G464 A468 Y75 H96 R100 M151 T254 R325 F378 R383 C385 G387 A391
BS02 CLR A Y112 S307 F310 F383 H385 Y75 S246 F249 F322 H324
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding

View graph for
Molecular Function
External links
PDB RCSB:6a15, PDBe:6a15, PDBj:6a15
PDBsum6a15
PubMed31182839
UniProtO64989|C90B1_ARATH Steroid (22S)-hydroxylase (Gene Name=CYP90B1)

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