Structure of PDB 6a04 Chain A

Receptor sequence
>6a04A (length=187) Species: 9823 (Sus scrofa) [Search protein sequence]
ANFNVAHGLAWSYYIGYLRLILPGLRARIQAYNQRHKNVLGGIGNHRLHI
LFPLDCGVPDDLSVADPNIRFLHELPQQSADRAGIKGRVYTNSIYELLEN
GQPAGVCVLEYATPLQTLFAMSQDGRAGFSREDRLEQAKLFCRTLEDILA
DAPEAQNNCRLIVYQEPTEGGSFSLSQEILRHLRQEE
3D structure
PDB6a04 Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2E A S162 Y167 I235 R238 Y240 T263 P264 S12 Y17 I85 R88 Y90 T113 P114 PDBbind-CN: -logKd/Ki=5.21,Kd=6.18uM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:6a04, PDBe:6a04, PDBj:6a04
PDBsum6a04
PubMed31167783
UniProtB8XX90|STING_PIG Stimulator of interferon genes protein (Gene Name=STING1)

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