Structure of PDB 5zza Chain A

Receptor sequence
>5zzaA (length=373) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
DETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDS
YVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHP
TLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIV
LDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVT
TAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGN
ERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGG
TTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTF
QQMWITKQEYDEAGPSIVHRKCF
3D structure
PDB5zza Genomes of Asgard archaea encode profilins that regulate actin.
ChainA
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LAB A T148 G168 F352 M355 T146 G166 F350 M353 BindingDB: IC50=8470nM
BS02 LAB A G15 L16 Q59 Y69 D157 R183 T186 R206 E207 R210 G13 L14 Q57 Y67 D155 R181 T184 R204 E205 R208 BindingDB: IC50=8470nM
BS03 ATP A G13 S14 G15 K18 G156 D157 G158 V159 G182 R210 K213 E214 G302 M305 Y306 G11 S12 G13 K16 G154 D155 G156 V157 G180 R208 K211 E212 G300 M303 Y304
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003785 actin monomer binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005523 tropomyosin binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0019904 protein domain specific binding
GO:0031013 troponin I binding
GO:0031432 titin binding
GO:0032036 myosin heavy chain binding
GO:0042802 identical protein binding
GO:0048306 calcium-dependent protein binding
GO:0140660 cytoskeletal motor activator activity
Biological Process
GO:0010628 positive regulation of gene expression
GO:0030041 actin filament polymerization
GO:0030240 skeletal muscle thin filament assembly
GO:0048741 skeletal muscle fiber development
GO:0051017 actin filament bundle assembly
GO:0090131 mesenchyme migration
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005865 striated muscle thin filament
GO:0005884 actin filament
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0031941 filamentous actin
GO:0032432 actin filament bundle
GO:0044297 cell body
GO:0098723 skeletal muscle myofibril

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5zza, PDBe:5zza, PDBj:5zza
PDBsum5zza
PubMed30283132
UniProtP68135|ACTS_RABIT Actin, alpha skeletal muscle (Gene Name=ACTA1)

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