Structure of PDB 5zyb Chain A

Receptor sequence
>5zybA (length=349) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
DPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVS
EQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSIT
MGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSI
GLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSK
EDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTH
KGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRQVLF
NKTGSSNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG
3D structure
PDB5zyb Crystal structure of MOX-1 complexed with a boronic acid transition state inhibitor S02030
ChainA
Resolution2.13 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S65 K68 Y151 E272 K312 S315
Catalytic site (residue number reindexed from 1) S59 K62 Y145 E266 K302 S305
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZXM A S65 Q121 Y151 Y223 G314 S315 S59 Q115 Y145 Y217 G304 S305
BS02 ZN A H187 D231 H181 D225
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space

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Molecular Function
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Cellular Component
External links
PDB RCSB:5zyb, PDBe:5zyb, PDBj:5zyb
PDBsum5zyb
PubMed
UniProtQ51578

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