Structure of PDB 5zvu Chain A

Receptor sequence
>5zvuA (length=381) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence]
SMQKLINSVQNYAWGSKTALTELYGIANPQQQPMAELWMGAHPKSSSRIT
TVSLRDAIEKNKTAMLGEAVANRFGELPFLFKVLCAAQPLSIQVHPNKRN
SEIGFAKENAPMDRNYKDPNHAPELVFALTPFLAMNAFREFSDIVSLLQP
VAGAHSAIAHFLQVPNAERLSQLFASLLNMQGEEKSRALAVLKAALNSQQ
GEPWQTIRVISEYYPDDSGLFSPLLLNVVKLNPGEAMFLFAETPHAYLQG
VALEVMANSDNVLRAGLTPKYIDIPELVANVKFEPKPAGELLTAPVKSGA
ELDFPIPVDDFAFSLHDLALQETSIGQHSAAILFCVEGEAVLRKDEQRLV
LKPGESAFIGADESPVNASGTGRLARVYNKL
3D structure
PDB5zvu Structural and functional insights into phosphomannose isomerase: the role of zinc and catalytic residues.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.3.1.8: mannose-6-phosphate isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H99 E134 H255 H95 E124 H245
Gene Ontology
Molecular Function
GO:0004476 mannose-6-phosphate isomerase activity
GO:0008270 zinc ion binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0009298 GDP-mannose biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5zvu, PDBe:5zvu, PDBj:5zvu
PDBsum5zvu
PubMed31063150
UniProtP25081|MANA_SALTY Mannose-6-phosphate isomerase (Gene Name=manA)

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