Structure of PDB 5zva Chain A

Receptor sequence
>5zvaA (length=184) Species: 9606 (Homo sapiens) [Search protein sequence]
ENLYFQGSAMDPPTFTFNFNNEPWVRGRHETYLCFTMEVVKHHSPVSWKR
GVFRNQTHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAE
FLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYC
WENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
3D structure
PDB5zva Crystal Structure of Cytidine Deaminase Human APOBEC3F Chimeric Catalytic Domain in Complex with DNA
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y333 K352 P353 W354 G356 K358 Y359 Y144 K163 P164 W165 G167 K169 Y170 PDBbind-CN: Kd=54.86uM
BS02 ZN A H249 C280 C283 H60 C91 C94
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:5zva, PDBe:5zva, PDBj:5zva
PDBsum5zva
PubMed
UniProtQ8IUX4|ABC3F_HUMAN DNA dC->dU-editing enzyme APOBEC-3F (Gene Name=APOBEC3F);
Q9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

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