Structure of PDB 5zuj Chain A

Receptor sequence
>5zujA (length=153) Species: 9606 (Homo sapiens) [Search protein sequence]
NGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPT
AQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEI
MDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEV
STL
3D structure
PDB5zuj Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R392 F410 E448 L456 L457 A458 R466 P468 K469 G470 F471 G472 Y473 T475 R43 F61 E99 L107 L108 A109 R117 P119 K120 G121 F122 G123 Y124 T126
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0016567 protein ubiquitination
GO:0043122 regulation of canonical NF-kappaB signal transduction

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5zuj, PDBe:5zuj, PDBj:5zuj
PDBsum5zuj
PubMed30378729
UniProtQ9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Gene Name=TRAF6)

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