Structure of PDB 5ztm Chain A

Receptor sequence
>5ztmA (length=168) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
MDIKSFLYQFCAKSQIEPKFDIRQTGPKNRQRFLCEVRVEPNTYIGVGNS
TNKKDAEKNACRDFVNYLVRVGKLNTNDVPAIHGNWTIENAKERLNIYKQ
TNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASK
SCALSLVRQLFHLNVIEP
3D structure
PDB5ztm Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila.
ChainA
Resolution2.899 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A D2 K4 S5 Y8 E17 K28 N29 F33 T51 N52 K53 K54 K58 K171 E172 N175 E195 H196 R198 F200 S222 N223 K224 K225 D2 K4 S5 Y8 E17 K28 N29 F33 T51 N52 K53 K54 K58 K92 E93 N96 E116 H117 R119 F121 S143 N144 K145 K146 PDBbind-CN: Kd=0.2uM
Gene Ontology
Molecular Function
GO:0003725 double-stranded RNA binding

View graph for
Molecular Function
External links
PDB RCSB:5ztm, PDBe:5ztm, PDBj:5ztm
PDBsum5ztm
PubMed30649456
UniProtP24785|MLE_DROME Dosage compensation regulator mle (Gene Name=mle)

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