Structure of PDB 5ztf Chain A

Receptor sequence
>5ztfA (length=972) Species: 9606 (Homo sapiens) [Search protein sequence]
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPATLLELVI
EQFEDLLVRILLLAACISFVLAWFTAFVEPFVILLILVANAIVGVWQERN
AENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPA
DIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSG
TNIAAGKAMGVVVATGVNTEIGKIRDEMRTPLQQKLDEFGEQLSKVISLI
CIAVWIINIGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRM
AKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDT
CSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALD
YNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIK
QLMKKEFTLEFSRDRKSMSVYCTPNKPSSMSKMFVKGAPEGVIDRCTHIR
VGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLE
DSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNK
GTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARV
EPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKT
ASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTA
ALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLI
SGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLKEDNP
DFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENI
WLVGSICLSMSLHFLILYVEPLPLIFQIPLNVTQWLMVLKISLPVILMDE
TLKFVARNYFVLLIMPLVIWVY
3D structure
PDB5ztf Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay.
ChainA
Resolution3.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.10: P-type Ca(2+) transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A D351 K352 T353 E442 F487 R489 M494 K514 R559 L561 G625 R677 N705 D325 K326 T327 E416 F461 R463 M468 K486 R531 L533 G597 R649 N677
BS02 MG A D351 T353 D702 D325 T327 D674
BS03 CA A A305 I307 E309 N795 D799 A279 I281 E283 N767 D771
BS04 CA A N767 E770 D799 E907 N739 E742 D771 E877
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005388 P-type calcium transporter activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0044325 transmembrane transporter binding
GO:0044548 S100 protein binding
GO:0046872 metal ion binding
GO:0086039 P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
GO:0106222 lncRNA binding
Biological Process
GO:0000045 autophagosome assembly
GO:0002026 regulation of the force of heart contraction
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0006984 ER-nucleus signaling pathway
GO:0007155 cell adhesion
GO:0008544 epidermis development
GO:0010460 positive regulation of heart rate
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0014883 transition between fast and slow fiber
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016240 autophagosome membrane docking
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration
GO:0033292 T-tubule organization
GO:0034220 monoatomic ion transmembrane transport
GO:0034599 cellular response to oxidative stress
GO:0034976 response to endoplasmic reticulum stress
GO:0045822 negative regulation of heart contraction
GO:0070050 neuron cellular homeostasis
GO:0070296 sarcoplasmic reticulum calcium ion transport
GO:0070588 calcium ion transmembrane transport
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction
GO:0140056 organelle localization by membrane tethering
GO:1900121 negative regulation of receptor binding
GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter
GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum
GO:1903779 regulation of cardiac conduction
GO:1990036 calcium ion import into sarcoplasmic reticulum
GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0031095 platelet dense tubular network membrane
GO:0033017 sarcoplasmic reticulum membrane
GO:0097470 ribbon synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ztf, PDBe:5ztf, PDBj:5ztf
PDBsum5ztf
PubMed31018135
UniProtP16615|AT2A2_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (Gene Name=ATP2A2)

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